The DNA sequence of human chromosome 22

作者：Ian Dunham, Adrienne R. Hunt, John E Collins, Richard Bruskiewich, David M. Beare, M. E. Clamp, Luc J Smink, R. Ainscough, J. P. Almeida, Anne Babbage, C. L. Bagguley, Jonathon Bailey, Karen F. Barlow, K. Bates, O. Beasley, Christine Bird, S. Blakey, Anne Bridgeman, David Buck, J. Burgess, W. Burrill, J.H. Burton, Carol Carder, N. P. Carter, Y. Chen, G.M.G. Clark, Sheila M. Clegg, V. Cobley, Charlotte G. Cole, R. E. Collier, R. Connor, D. Conroy, N. Corby, G. J. Coville, Amelia Cox, John Dean Davis, Elisabeth Dawson, Pawandeep Dhami, Cat Dockree, Steve Dodsworth, Richard M. Durbin, Andrew Ellington, Kathryn Louise Evans, Jim Fey, Keiran Fleming, Lisa French, A. A. Garner, James G. R. Gilbert, Melanie E. Goward, Darren V. Grafham, Mark N. D. Griffiths, C. Hall, R. E. Hall, G. Hall-Tamlyn, Rosemary W. Heathcott, Sarah K Ho, S. Holmes, Sarah E Hunt, Matthew Clement Jones, J. K. Kershaw, A. M. Kimberley, ANDREW G. KING, Gavin K. Laird, Cordelia F. Langford, M. Leversha, Christine Lloyd, David Lloyd, I. D. Martyn, Maryam Mashreghi-Mohammadi, L. Matthews, O. T. McCann, Joseph L. McClay, Stuart McLaren, Amanda A. McMurray, Stuart A. Milne, Beverley Mortimore, C. Odell, Rebecca Pavitt, A. V. Pearce, D. Pearson, Benjamin Phillimore, S. H. Phillips, R. W. Plumb, H. P. Ramsay, Y. Ramsey, Layne W. Rogers, Matthew T. Ross, Carol Scott, Harminder Sehra, C. D. Skuce, Susan L. Smalley, M. L. Smith, Cari Soderlund, L. Spragon, Charles A. Steward, John Sulston, R. Mark Swann, Mark D. Vaudin, M. Wall, J. M. Wallis, Mathew N. Whiteley, Dave Willey, Leanne E. Williams, S. Williams, HELEN STUART WILLIAMSON, T. E. Wilmer, Laurens G. Wilming, C. L. Wright, Tim Hubbard, D. R. Bentley, Stephan Beck, Jane Rogers, Nobutaka Shimizu, Satoshi Minoshima, Kazuhiko Kawasaki, Takashi Sasaki, Shuichi Asakawa, Jun Kudoh, Ai Shintani, Kazunori Shibuya, Yumiko Yoshizaki, Nanako Aoki, Susumu Mitsuyama, B.A. Roe, F. Chen, L Chu, Judy S. Crabtree, Stéphane Deschamps, Ahn Do, Thuy Do, Alexandra Dorman, Ferric C. Fang, Ying Fu, Ping Hu, Axin Hua, Steve Kenton, Hongshing Lai, Houyuan Lao, Jennifer D. Lewis, Suzanna E. Lewis, Shau‐Ping Lin, Po‐Ru Loh, Eda Malaj, Thi Huyen NGUYEN, Huaqin Helen Pan, Stephen Phan, Sulan Qi, Y. Qian, L. Ray, Qun Ren, Steve Shaull, Daniel B. Sloan, Linsheng Song, Qixuan Wang, Y. Wang, Z. Wang, James David White, Darrin L. Willingham, H. Wu, Ziyun Yao, Ming Zhan, G. Zhang, Stephanie L. Chissoe, J. Murray, Nancy Miller, Pat Minx, Robert S. Fulton, D. Johnson, Guy W. Bemis, D. R. Bentley, H. D. Bradshaw, Steve Bourne, M. Cordes, Zhiwei Du, Lucinda A. Fulton, D. Goela, Tina Graves, John S. Hawkins, K. Hinds, K. Kemp, Phil Latreille, Dan Layman, Philip Ozersky, Theresa Rohlfing, Paul A. Scheet, Calvin C Walker, A. Wamsley, Patricia E. Wohldmann, Kymberlie Pepin, Joanne O. Nelson, Ian F. Korf, J. A. Bedell, LaDeana Hillier, Elaine R. Mardis, R Waterston, Richard Wilson, Beverly S. Emanuel, Tamim H. Shaikh, Hiroki Kurahashi, Sulagna C. Saitta, Marcia L. Budarf, Heather E. McDermid, A. Johnson, Andrew C.C. Wong, Bernice E. Morrow, Lisa J. Edelmann, U. J. Kim, H. Shizuya, Melvin I. Simon, Jan Piotr Dumanski, Myriam Peyrard, Darek Kedra, Eyal Seroussi, Ingegerd Fransson, I. Tapia, Carl E.G. Bruder, Kevin P. O'Brien · 发表于：Nature · 年份：1999 · DOI：10.1038/990031 · 被引用次数：1167 · 研究领域：RNA and protein synthesis mechanisms、Genomics and Phylogenetic Studies、Chromosomal and Genetic Variations

Knowledge of the complete genomic DNA sequence of an organism allows a systematic approach to defining its genetic components. The genomic sequence provides access to the complete structures of all genes, including those without known function, their control elements, and, by inference, the proteins they encode, as well as all other biologically important sequences. Furthermore, the sequence is a rich and permanent source of information for the design of further biological studies of the organism and for the study of evolution through cross-species sequence comparison. The power of this approach has been amply demonstrated by the determination of the sequences of a number of microbial and model organisms. The next step is to obtain the complete sequence of the entire human genome. Here we report the sequence of the euchromatic part of human chromosome 22. The sequence obtained consists of 12 contiguous segments spanning 33.4 megabases, contains at least 545 genes and 134 pseudogenes, and provides the first view of the complex chromosomal landscapes that will be found in the rest of the genome.