Simultaneous B and T cell acute lymphoblastic leukemias in zebrafish driven by transgenic MYC: implications for oncogenesis and lymphopoiesis

作者：Chiara Borga, Gilseung Park, Clay A. Foster, Jessica Burroughs-Garcìa, Matteo Marchesin, Rikin K. Shah, Ameera Hasan, Syed Talha Ahmed, Silvia Bresolin, Lance A. Batchelor, Teresa Scordino, Rodney R. Miles, Geertruy te Kronnie, James L. Regens, John Kimble Frazer · 发表于：Leukemia · 年份：2018 · DOI：10.1038/s41375-018-0226-6 · 被引用次数：41 · 研究领域：Zebrafish Biomedical Research Applications、Acute Lymphoblastic Leukemia research、Epigenetics and DNA Methylation

Precursor-B cell acute lymphoblastic leukemia (pre-B ALL) is the most common pediatric cancer, but there are no useful zebrafish pre-B ALL models. We describe the first highly- penetrant zebrafish pre-B ALL, driven by human MYC. Leukemias express B lymphoblast-specific genes and are distinct from T cell ALL (T-ALL)-which these fish also develop. Zebrafish pre-B ALL shares in vivo features and expression profiles with human pre-B ALL, and these profiles differ from zebrafish T-ALL or normal B and T cells. These animals also exhibit aberrant lymphocyte development. As the only robust zebrafish pre-B ALL model and only example where T-ALL also develops, this model can reveal differences between MYC-driven pre-B vs. T-ALL and be exploited to discover novel pre-B ALL therapies.