Spatiotemporal structure of cell fate decisions in murine neural crest

作者：Ruslan Soldatov, Markéta Kaucká, Maria Eleni Kastriti, Julian Petersen, Tatiana Chontorotzea, Lukas Englmaier, Natalia Akkuratova, Yunshi Yang, Martin Häring, Vyacheslav Dyachuk, Christoph Bock, Matthias Farlik, Michael L. Piacentino, Franck Boismoreau, Markus M. Hilscher, Chika Yokota, Xiaoyan Qian, Mats Nilsson, Marianne Bronner‐Fraser, Laura Croci, Wen-Yu Hsiao, David A. Guertin, Jean‐François Brunet, G. Giacomo Consalez, Patrik Ernfors, Kaj Fried, Peter V. Kharchenko, Igor Adameyko · 发表于：Science · 年份：2019 · DOI：10.1126/science.aas9536 · 被引用次数：577 · 研究领域：Single-cell and spatial transcriptomics、RNA Research and Splicing、Genomics and Chromatin Dynamics

Binary decisions refine fate decisions Neural crest cells develop into tissues ranging from craniofacial bones to peripheral neurons. Combining single-cell RNA sequencing with spatial transcriptomics, Soldatov et al. analyzed how neural crest cells in mouse embryos decide among the various fates available to them (see the Perspective by Mayor). These multipotent cells become biased toward a given fate early on and step through a progression of binary decisions as their fate is refined. Competing fate programs coexist until increased synchronization favors one and repression disfavors the other. Science , this issue p. eaas9536 ; see also p. 937