The endoderm: a divergent cell lineage with many commonalities

作者：Sonja Nowotschin, Anna‐Katerina Hadjantonakis, Kyra Campbell · 发表于：Development · 年份：2019 · DOI：10.1242/dev.150920 · 被引用次数：99 · 研究领域：Cancer Cells and Metastasis、Developmental Biology and Gene Regulation、Congenital heart defects research

The endoderm is a progenitor tissue that, in humans, gives rise to the majority of internal organs. Over the past few decades, genetic studies have identified many of the upstream signals specifying endoderm identity in different model systems, revealing them to be divergent from invertebrates to vertebrates. However, more recent studies of the cell behaviours driving endodermal morphogenesis have revealed a surprising number of shared features, including cells undergoing epithelial-to-mesenchymal transitions (EMTs), collective cell migration, and mesenchymal-to-epithelial transitions (METs). In this Review, we highlight how cross-organismal studies of endoderm morphogenesis provide a useful perspective that can move our understanding of this fascinating tissue forward.