Importance of the relationship between symptoms and self-reported physical activity level in stable COPD based on the results from the SPACE study

作者：Florin Mihălţan, Yochai Adir, Adam Antczak, Κonstantinos Porpodis, Vesna Radulović, Nuno Pires, Geeuwke J. de Vries, Andreas Horner, Samuel De Bontridder, Yunqin Chen, Anat Shavit, Silviu Alecu, L. Adamek · 发表于：Respiratory Research · 年份：2019 · DOI：10.1186/s12931-019-1053-7 · 被引用次数：33 · 研究领域：Chronic Obstructive Pulmonary Disease (COPD) Research、Delphi Technique in Research、Cardiovascular Health and Risk Factors

BACKGROUND: The burden of symptoms and risk of exacerbations are the main drivers of the overall assessment of the Chronic Obstructive Pulmonary Disease (COPD) and the adequate treatment approaches per current Global Initiative for Chronic Obstructive Lung Disease (GOLD). Physical activity has emerged as both functional outcome and non-pharmacological intervention in COPD patients, despite the lack of standardized measures or guidelines in clinical practice. This study aimed to explore in more depth the 24-h respiratory symptoms, the physical activity level (PAL) and the relationship between these two determinants in stable COPD patients. METHODS: This was a multinational, multicenter, observational, cross-sectional study conducted in ten European countries and Israel. Dedicated questionnaires for each part of the day (morning, daytime, night) were used to assess respiratory symptoms. PAL was evaluated with self- and interview-reported tools [EVS (exercise as vital sign) and YPAS (Yale Physical Activity Survey)], and physician's judgement. Patients were stratified in ABCD groups by 2013 and 2017 GOLD editions using the questionnaires currently recommended: modified Medical Research Council dyspnea scale and COPD Assessment Test. RESULTS: The study enrolled 2190 patients (mean age: 66.9 years; male: 70.0%; mean % predicted FEV1: 52.6; GOLD groups II-III: 84.5%; any COPD treatment: 98.9%). Most patients (> 90%) reported symptoms in any part of the 24-h day, irrespective of COPD...