Ultrasonication-Triggered Ubiquitous Assembly of Magnetic Janus Amphiphilic Nanoparticles in Cancer Theranostic Applications

作者：Xiaoli Liu, Mingli Peng, Galong Li, Yuqing Miao, Hao Luo, Guangyin Jing, Yuan He, Ce Zhang, Fan Zhang, Haiming Fan · 发表于：Nano Letters · 年份：2019 · DOI：10.1021/acs.nanolett.9b01524 · 被引用次数：54 · 研究领域：Pickering emulsions and particle stabilization、Nanoparticle-Based Drug Delivery、Proteins in Food Systems

The ultrasonication-triggered interfacial assembly approach was developed to synthesize magnetic Janus amphiphilic nanoparticles (MJANPs) for cancer theranostic applications, where the biocompatible octadecylamine is used as a molecular linker to mediate the interactions between hydrophobic and hydrophilic nanoparticles across the oil–water interface. The obtained Co cluster-embedded Fe 3 O 4 nanoparticles–graphene oxide (CCIO–GO) MJANPs exhibited superior magnetic heating efficiency and transverse relaxivity, 64 and 4 times higher than that of commercial superparamagnetic iron oxides, respectively. The methodology has been applicable to nanoparticles of various dimensions (5–100 nm), morphologies (sphere, ring, disk, and rod), and composition (metal oxides, noble metal and semiconductor compounds, etc. ), thereby greatly enriching the array of MJANPs. In vivo theranostic applications using the tumor-bearing mice model further demonstrated the effectiveness of these MJANPs in high-resolution multimodality imaging and high-efficiency cancer therapeutics. The ubiquitous assembly approach developed in the current study pave the way for on-demand design of high-performance Janus amphiphilic nanoparticles for various clinical diagnoses and therapeutic applications.