Photoinduced, Copper-Catalyzed Radical Cross-Coupling of Cycloketone Oxime Esters, Alkenes, and Terminal Alkynes

作者：Jun Chen, Jun Chen, Bin‐Qing He, Peng‐Zi Wang, Xiaoye Yu, Quanqing Zhao, Jia‐Rong Chen, Jia‐Rong Chen, Wen‐Jing Xiao · 发表于：Organic Letters · 年份：2019 · DOI：10.1021/acs.orglett.9b01529 · 被引用次数：100 · 研究领域：Radical Photochemical Reactions、Catalytic C–H Functionalization Methods、Sulfur-Based Synthesis Techniques

A photoinduced, copper-catalyzed three-component radical cross-coupling of cycloketone oxime esters, alkenes, and terminal alkynes is described for the first time. Key to the success of this process was the integration of photoinduced iminyl radical-mediated C-C bond cleavage with the conceptual simplicity of copper-catalyzed radical cross-coupling. This protocol provides access to cyanoalkyl-containing propargylic compounds in good yields.