Direct Csp 3 –H methylenation of 2-arylacetamides using DMF/Me 2 NH-BH 3 as the methylene source

作者：Yuting Liu, Chang-Ling Wang, Huimin Xia, Zhijuan Wang, Yi‐Feng Wang · 发表于：Organic & Biomolecular Chemistry · 年份：2019 · DOI：10.1039/c9ob00875f · 被引用次数：7 · 研究领域：Catalytic C–H Functionalization Methods、Catalytic Cross-Coupling Reactions、Asymmetric Hydrogenation and Catalysis

A direct Csp3-H methylenation of 2-arylacetamides using DMF/Me2NH-BH3 as the methylene source was developed. The formyl group of DMF delivered the carbon and one hydrogen atoms, and the Me2NH-BH3 donated the remaining one hydrogen atom. This protocol offers a new alternative to make useful 2-arylacrylamides from simple starting materials.