Adverse organogenesis and predisposed long-term metabolic syndrome from prenatal exposure to fine particulate matter

作者：Guoyao Wu, Jacob D. Brown, Misti Levy Zamora, Alyssa Miller, Michael Carey Satterfield, Cynthia J. Meininger, Chelsie B. Steinhauser, Gregory A. Johnson, Robert C. Burghardt, Fuller W. Bazer, Yixin Li, Natalie M. Johnson, Mario J. Molina, Renyi Zhang · 发表于：Proceedings of the National Academy of Sciences · 年份：2019 · DOI：10.1073/pnas.1902925116 · 被引用次数：78 · 研究领域：Air Quality and Health Impacts、Climate Change and Health Impacts、Birth, Development, and Health

of ultrafine aerosols of ammonium sulfate. At birth (postnatal day 0, PND0), four males and four females were selected randomly from each litter to be nursed by dams, whereas tissues were collected from the remaining pups. At PND21, tissues were collected from two males and two females, whereas the remaining pups were fed either a high- or low-fat diet until PND105, when tissues were obtained for biochemical and physiological analyses. Maternal exposure to fine PM increased stillbirths; reduced gestation length and birth weight; increased concentrations of glucose and free fatty acids in plasma; enhanced lipid accumulation in the liver; and decreased endothelium-dependent relaxation of aorta. This lead to altered organogenesis and predisposed progeny to long-term metabolic defects in an age-, organ-, and sex-specific manner. Our results highlight the necessity to develop therapeutic strategies to remedy adverse health effects of maternal PM exposure on conceptus/postnatal growth and development.