Rh(III)-Catalyzed Oxidative Spirocyclization of Isoquinolones with α-Diazo-1,3-indandiones

作者：Shenghai Guo, Lincong Sun, Yangfan Liu, Nana Ma, Xinying Zhang, Xuesen Fan · 发表于：Organic Letters · 年份：2019 · DOI：10.1021/acs.orglett.9b01263 · 被引用次数：48 · 研究领域：Catalytic C–H Functionalization Methods、Cyclopropane Reaction Mechanisms、Synthesis and Catalytic Reactions

Rh(III)-catalyzed site-selective oxidative spirocyclization reactions of isoquinolones with α-diazo-1,3-indandiones leading to three kinds of spiro compounds by employing isoquinolones with different structural features or tuning the reaction parameters are presented. In addition, a plausible catalytic cycle is proposed on the basis of control experimental results and density functional theory calculations. Finally, the diverse transformations of the spiro products into other complex skeletons demonstrate the synthetic utility of this protocol.