Identification of a novel orally bioavailable ERK5 inhibitor with selectivity over p38α and BRD4

作者：Stephanie M. Myers, Duncan C. Miller, Lauren Molyneux, Mercedes Arasta, Ruth H. Bawn, Timothy J. Blackburn, Simon J. Cook, Noel Edwards, Jane Endicott, Bernard T. Golding, Roger J. Griffin, Tim R. Hammonds, Ian R. Hardcastle, Suzannah J. Harnor, Amy B. Heptinstall, Pamela A. Lochhead, Mathew P. Martin, Nick C. Martin, David R. Newell, Paul Owen, Leon Pang, Tristan D. Reuillon, Laurent J. M. Rigoreau, Huw D. Thomas, Julie A. Tucker, Lan-Zhen Wang, Ai-Ching Wong, Martin E. M. Noble, Stephen R. Wedge, Céline Cano · 发表于：European Journal of Medicinal Chemistry · 年份：2019 · DOI：10.1016/j.ejmech.2019.05.057 · 被引用次数：22 · 研究领域：Melanoma and MAPK Pathways、Protein Kinase Regulation and GTPase Signaling、Cancer Mechanisms and Therapy