<p>Chronic stress increases susceptibility to food addiction by increasing the levels of DR2 and MOR in the nucleus accumbens</p>

作者：Naili Wei, Zi-Fang Quan, Tong Zhao, Xudong Yu, Qiang Xie, Jun Zeng, Fukai Ma, Fan Wang, Qisheng Tang, Heng Wu, Jianhong Zhu · 发表于：Neuropsychiatric Disease and Treatment · 年份：2019 · DOI：10.2147/ndt.s204818 · 被引用次数：47 · 研究领域：Stress Responses and Cortisol、Adipose Tissue and Metabolism、Eating Disorders and Behaviors

Chronic stress increases susceptibility to food addiction by increasing the levels of DR2 and MOR in the nucleus accumbens Nai-Li Wei,1,2 Zi-Fang Quan,3,4 Tong Zhao,1 Xu-Dong Yu,4 Qiang Xie,1 Jun Zeng,1 Fu-Kai Ma,1 Fan Wang,1 Qi-Sheng Tang,1 Heng Wu,3 Jian-Hong Zhu11Fudan University Huashan Hospital, Department of Neurosurgery, State Key Laboratory for Medical neurobiology, Institutes of Brain Science, Shanghai Medical College-Fudan University, Shanghai, 20040, People’s Republic of China; 2Department of Neurosurgery, The Second Hospital of Lanzhou University, Lanzhou Gansu China, 730030, People’s Republic of China; 3Department of Neurology, The First Affiliated Hospital, University of South China, Hengyang, Hunan, 421001, People’s Republic of China; 4Institute of Neuroscience, Medical College, University of South China, Hengyang, Hunan, 421001, People’s Republic of ChinaBackground: Stress-related obesity might be related to the suppression of the hypothalamic-pituitary- adrenocortical axis and dysregulation of the metabolic system. Chronic stress also induces the dysregulation of the reward system and increases the risk of food addiction, according to recent clinical findings. However, few studies have tested the effect of chronic stress on food addiction in animal models.Purpose: The objective of this study was to identify whether chronic stress promotes food addiction or not and explore the possible mechanisms.Method: We applied adaily 2 hrsflashing LED irradiation stress t...