Ganoderic acid A attenuates lipopolysaccharide-induced lung injury in mice

作者：Bing Wan, Yan Li, Shuangshuang Sun, Yang Yang, Yanling Lv, Li Wang, Meijuan Song, Meizi Chen, Chengjiang Wu, Hangcheng Pan, Xiuwei Zhang · 发表于：Bioscience Reports · 年份：2019 · DOI：10.1042/bsr20190301 · 被引用次数：29 · 研究领域：Immune Response and Inflammation、Respiratory Support and Mechanisms、NF-κB Signaling Pathways

The present study aimed to investigate the protective effects of ganoderic acid A (GAA) on lipopolysaccharide (LPS)-induced acute lung injury. In mouse model of LPS-induced acute lung injury, we found that GAA led to significantly lower lung wet-to-dry weight ratio and lung myeloperoxidase activity, and attenuated pathological damages. In addition, GAA increased superoxide dismutase activity, but decreased malondialdehyde content and proinflammatory cytokines levels in the bronchoalveolar lavage fluid. Mechanistically, GAA reduced the activation of Rho/ROCK/NF-κB pathway to inhibit LPS-induced inflammation. In conclusion, our study suggests that GAA attenuates acute lung injury in mouse model via the inhibition of Rho/ROCK/NF-κB pathway.