The Relationship Between Serum Concentration of Vitamin D, Total Intracranial Volume, and Severity of Depressive Symptoms in Patients With Major Depressive Disorder

作者：Daomin Zhu, Wenming Zhao, Biao Zhang, Yu Zhang, Ying Yang, Cun Zhang, Yajun Wang, Jiajia Zhu, Yongqiang Yu · 发表于：Frontiers in Psychiatry · 年份：2019 · DOI：10.3389/fpsyt.2019.00322 · 被引用次数：36 · 研究领域：Vitamin D Research Studies、Stress Responses and Cortisol、Tryptophan and brain disorders

Background: Depression has been linked to vitamin D deficiency. However, little attention was paid to the neural substrate underlying this association. Methods: 50 patients with major depressive disorder (MDD) were enrolled in this study. High-resolution structural magnetic resonance imaging was performed to calculate total intracranial volume (TIV). Peripheral venous blood samples were collected to measure serum vitamin D concentration. Hamilton Rating Scale for Depression (HAMD) was used to assess severity of depression symptoms. The relationship among TIV, serum vitamin D concentration and HAMD score was examined using correlation, linear regression and mediation analyses. Results: In patients with MDD, HAMD score was negatively correlated with TIV and serum vitamin D concentration, and TIV was positively correlated with serum vitamin D concentration. Linear regression analyses showed TIV and serum vitamin D concentration were significant predictors of HAMD score. Importantly, mediation analysis revealed that TIV significantly mediated the relationship between serum vitamin D concentration and HAMD score. Conclusion: Our findings suggest that TIV may serve as a potential neural biomarker for monitoring responses to adjuvant therapy of vitamin D in patients with MDD.