Co-Delivery of Paclitaxel and PLK1-Targeted siRNA Using Aptamer-Functionalized Cationic Liposome for Synergistic Anti-Breast Cancer Effects In Vivo

作者：Yu Sheng, Xiongjie Bi, Lei Yang, WU Shan-guang, Yating Yu, Bojin Jiang, Anwen Zhang, Ke Lan, Siliang Duan · 发表于：Journal of Biomedical Nanotechnology · 年份：2019 · DOI：10.1166/jbn.2019.2751 · 被引用次数：98 · 研究领域：Advanced biosensing and bioanalysis techniques、RNA Interference and Gene Delivery、Nanoparticle-Based Drug Delivery

. The simultaneous delivery of PTX and siRNA synergistically increased the number of apoptotic cells and reduced angiogenesis. This delivery method exhibited significant advantages over combined delivery of PTX and siRNA separately by different liposomal drug delivery systems. Therefore, the simultaneous delivery of PTX and PLK1-targeted siRNA using AS1411 aptamer-functionalized liposome may have good potential clinical value for the therapy of breast cancer. Nanomedicine based on simultaneous delivery of chemotherapy drugs and siRNA gene provides an effective platform for improving tumor treatment methods.