CACNA1C (rs1006737) may be a susceptibility gene for schizophrenia: An updated meta‐analysis

作者：Dongjian Zhu, Jingwen Yin, Chunmei Liang, Xudong Luo, Dong Lv, Zhun Dai, Susu Xiong, Jiawu Fu, You Li, Juda Lin, Zhixiong Lin, Yajun Wang, Guoda Ma · 发表于：Brain and Behavior · 年份：2019 · DOI：10.1002/brb3.1292 · 被引用次数：41 · 研究领域：Genetic Associations and Epidemiology、Phosphodiesterase function and regulation、Ion channel regulation and function

INTRODUCTION: Schizophrenia is a serious mental illness with a genetic predisposition. Genome-wide association studies (GWAS) have identified the α-1C subunit of the L-type voltage-gated calcium channel (CACNA1C) gene as a significant risk gene for schizophrenia. However, there are inconsistent conclusions in case-control studies. METHODS: We performed a comprehensive meta-analysis of all available samples from existing studies under four different genetic models (recessive model, dominant model, additive model and allele model) to further confirm whether CACNA1C rs1006737 is an authentic risk single nucleotide polymorphism (SNP) for schizophrenia. RESULTS: A statistically significant difference under the four models (all p < 0.05) was observed by pooling nine Asian and European studies, including a total of 12,744 cases and 16,460 controls. For European-decent samples, a significant difference was identified between patients and controls for the four models (all p < 0.05). We observed a significant difference between patients and controls for the recessive model and allele model (GG vs. GA + AA: p < 0.00001; G vs. A: p < 0.00001) using a fixed effect model, but the dominant model (GG + GA vs. AA: OR: p = 0.15) and additive model (GG vs. AA: p = 0.11) showed no significant difference between patients and controls in the Asian samples. CONCLUSION: Our findings provide important evidence for the establishment of CACNA1C as a susceptibility gene for schizophrenia across world po...