Risk of HIV transmission through condomless sex in serodifferent gay couples with the HIV-positive partner taking suppressive antiretroviral therapy (PARTNER): final results of a multicentre, prospective, observational study

作者：Alison Rodger, Valentina Cambiano, Tina Bruun, Pietro Vernazza, Simon Collins, Olaf Degen, Giulio Maria Corbelli, Vicente Estrada, Anna María Geretti, Apostolos Beloukas, Dorthe Raben, Pep Coll, Andrea Antinori, Nneka Nwokolo, Armin Rieger, Jan M. Prins, Anders Blaxhult, Rainer Weber, Arne van Eeden, Norbert H. Brockmeyer, Amanda Clarke, Jorge del Romero Guerrero, F. Raffi, Johannes R. Bogner, Gilles Wandeler, Jan Gerstoft, Félix Gutiérrez, Kees Brinkman, Maria Kitchen, Lars Ostergaard, Agathe León, Matti Ristola, Heiko Jessen, Hans‐Jürgen Stellbrink, Andrew Phillips, Jens Lundgren, Pep Coll, Patricia Cobarsí, Aroa Nieto, Michael Meulbroek, Antonia Carrillo, Jorge Saz, Jorge D.R. Guerrero, Mar Vera García, Félix Gutiérrez, Mar Masiá, Catalina Robledano, Agathe León, Lorna Leal, Eva G. Redondo, Vicente Estrada, Rocio Marquez, Raquel Sandoval, Pompeyo Viciana, Núria Espinosa, Luís F. López‐Cortés, Daniel Podzamczer, Juan Tiraboschi, Sandra Morenilla, Antonio Antela, Elena Losada, Nneka Nwokolo, Janey Sewell, Amanda Clarke, S Kirk, Alyson Knott, Alison Rodger, Thomas Fernandez, Mark Gompels, Louise Jennings, Lana Ward, Julie Fox, Julianne Lwanga, Ming Lee, Richard Gilson, Clifford Leen, Sheila Morris, Dan Clutterbuck, Michael Brady, David Asboe, Serge Fedele, Sarah Fidler, Norbert H. Brockmeyer, Anja Potthoff, Adriane Skaletz‐Rorowski, Johannes R. Bogner, Ulrich Seybold, Julia Roider, Heiko Jessen, Arne Jessen, Slobodan Ruzicic, Hans‐Jürgen Stellbrink, Tim Kümmerle, Clara Lehmann, Olaf Degen, Sindy Bartel, Anja Hüfner, Jürgen K. Rockstroh, Karina Mohrmann, Christoph Boesecke, Ivanka Krznaric, Patrick Ingiliz, Rainer Weber, Christina Grube, Dominique L. Braun, Huldrych F. Günthard, Gilles Wandeler, Hansjakob Furrer, Andri Rauch, Pietro Vernazza, Patrick Schmid, Manuela Rasi, Denise Borso, Markus Stratmann, Oliver Caviezel, Marcel Stoeckle, Manuel Battegay, Philip Tarr, Vanessa Christinet, Florent Jouinot, Camille Isambert, Enos Bernasconi, Beatrice Bernasconi, Jan Gerstoft, Lene Pors Jensen, Anne A. Bayer, Lars Ostergaard, Yordanos Yehdego, Ann Bach, Pia Handberg, Gitte Kronborg, Svend s. Pedersen, Nete Bülow, Bente Ramskover, Matti Ristola, Outi Debnam, Jussi Sutinen, Anders Blaxhult, Ronnie Ask, Bernt Hildingsson-Lundh, Katarina Westling, Eeva-Maija Frisen, Gráinne Cortney, Siobhán O’Dea, Stéphane De Wit, Coca Necsoi, Linos Vandekerckhove, Jean‐Christophe Goffard, Sophie Henrard, Jan M. Prins, Hans-Henrik Nobel, Annouschka M. Weijsenfeld, Arne van Eeden, L. Elsenburg, Kees Brinkman, Danielle Vos, Imke Hoijenga, Elisabeth H. Gisolf, Petra van Bentum, D.W.M. Verhagen, F. Raffi, Éric Billaud, Michel Ohayon, Daniel Gosset, Alexandre Fior, Gilles Pialoux, Pélagie Thibaut, Julie Chas, Vincent Leclercq, V Péchenot, Vincent Coquelin, Christian Pradier, S Bréaud, Veronique Touzeau-Romer, Armin Rieger, Maria Geit, Mario Sarcletti, Martin Gisinger, Angela Oellinger, Andrea Antinori, Samanta Menichetti, Teresa Bini, Cristina Mussini, Marianna Meschiari, Antonio Di Biagio, Lucia Taramasso, Benedetto Maurizio Celesia, Maria Gussio, Nuno Janeiro · 发表于：The Lancet · 年份：2019 · DOI：10.1016/s0140-6736(19)30418-0 · 被引用次数：1015 · 研究领域：HIV/AIDS Research and Interventions、HIV Research and Treatment、HIV/AIDS drug development and treatment

BACKGROUND: The level of evidence for HIV transmission risk through condomless sex in serodifferent gay couples with the HIV-positive partner taking virally suppressive antiretroviral therapy (ART) is limited compared with the evidence available for transmission risk in heterosexual couples. The aim of the second phase of the PARTNER study (PARTNER2) was to provide precise estimates of transmission risk in gay serodifferent partnerships. METHODS: The PARTNER study was a prospective observational study done at 75 sites in 14 European countries. The first phase of the study (PARTNER1; Sept 15, 2010, to May 31, 2014) recruited and followed up both heterosexual and gay serodifferent couples (HIV-positive partner taking suppressive ART) who reported condomless sex, whereas the PARTNER2 extension (to April 30, 2018) recruited and followed up gay couples only. At study visits, data collection included sexual behaviour questionnaires, HIV testing (HIV-negative partner), and HIV-1 viral load testing (HIV-positive partner). If a seroconversion occurred in the HIV-negative partner, anonymised phylogenetic analysis was done to compare HIV-1 pol and env sequences in both partners to identify linked transmissions. Couple-years of follow-up were eligible for inclusion if condomless sex was reported, use of pre-exposure prophylaxis or post-exposure prophylaxis was not reported by the HIV-negative partner, and the HIV-positive partner was virally suppressed (plasma HIV-1 RNA <200 copies per m...