Respiratory Syncytial Virus Seasonality, Beijing, China, 2007–2015

作者：Jianxing Yu, Chunyan Liu, Yan Xiao, Zichun Xiang, Hongli Zhou, Lan Chen, Kunling Shen, Zhengde Xie, Lili Ren, Jianwei Wang · 发表于：Emerging infectious diseases · 年份：2019 · DOI：10.3201/eid2506.180532 · 被引用次数：107 · 研究领域：Respiratory viral infections research、Pneumonia and Respiratory Infections、Neonatal Respiratory Health Research

During July 2007-June 2015, we enrolled 4,225 hospitalized children with pneumonia in a study to determine the seasonality of respiratory syncytial virus (RSV) infection in Beijing, China. We defined season as the period during which >10% of total PCRs performed each week were RSV positive. We identified 8 distinctive RSV seasons. On average, the season onset occurred at week 41 (mid-October) and lasted 33 weeks, through week 20 of the next year (mid-May); 97% of all RSV-positive cases occurred during the season. RSV seasons occurred 3-5 weeks earlier and lasted ≈6 weeks longer in RSV subgroup A-dominant years than in RSV subgroup B-dominant years. Our analysis indicates that monitoring such RSV subgroup shifts might provide better estimates for the onset of RSV transmission. PCR-based tests could be a flexible or complementary way of determining RSV seasonality in locations where RSV surveillance is less well-established, such as local hospitals throughout China.