Lipid Modulating Anti-oxidant Stress Activity of Gastrodin on Nonalcoholic Fatty Liver Disease Larval Zebrafish Model

作者：Owais Ahmad, Bing Wang, Kejian Ma, Yang Deng, Maoru Li, Liping Yang, Yuqi Yang, Jingyun Zhao, Lijun Cheng, Qinyang Zhou, Jing Shang · 发表于：International Journal of Molecular Sciences · 年份：2019 · DOI：10.3390/ijms20081984 · 被引用次数：56 · 研究领域：Biological and pharmacological studies of plants、Neuroendocrine regulation and behavior、Circadian rhythm and melatonin

Non-alcoholic fatty liver disease (NAFLD) and nonalcoholic steatohepatitis (NASH) is the most common chronic liver disease in the world. However, there are still no drugs for NAFLD/NASH in the market. Gastrodin (GAS) is a bioactive compound that is extracted from Gastrodia elata, which is used as an active compound on nervous system diseases. Recent reports showed that GAS and Gastrodia elata possess anti-oxidant activity and lipid regulating effects, which makes us curious to reveal the anti-NAFLD effect of GAS. A high cholesterol diet (HCD) was used to induce a NAFLD larval zebrafish model, and the lipid regulation and anti-oxidant effects were tested on the model. Furthermore, qRT-PCR studied the underlying mechanism of GAS. To conclude, this study revealed a lipid regulation and anti-oxidant insights of GAS on NAFLD larval zebrafish model and provided a potential therapeutic compound for NAFLD treatment.