Functional Connectivity Changes Across the Spectrum of Subjective Cognitive Decline, Amnestic Mild Cognitive Impairment and Alzheimer’s Disease

作者：Ziqi Wang, Kaini Qiao, Guanqun Chen, Danyang Sui, Hao-Ming Dong, Yinshan Wang, Hui‐Jie Li, Jie Lu, Xi‐Nian Zuo, Ying Han · 发表于：Frontiers in Neuroinformatics · 年份：2019 · DOI：10.3389/fninf.2019.00026 · 被引用次数：49 · 研究领域：Functional Brain Connectivity Studies、Dementia and Cognitive Impairment Research、Neural and Behavioral Psychology Studies

The abnormality occurs at molecular, cellular as well as network levels in patients with Alzheimer’s disease (AD) prior to diagnosis. Most previous connectivity studies were conducted at 1 out of 3 (local, meso and global) scales in subjects covering only part of the entire AD spectrum (subjective cognitive decline, SCD; amnestic mild cognitive impairment, aMCI; and then fully manifest AD). Data interpretation within the framework of disease progression is thus difficult. The current study included 3 age- and sex-matched cohorts: SCD (n=32), aMCI (n=37) and fully-established AD (n=30). A group of healthy elderly subjects (n=40) was included as normal control (NC). Network connectivity was examined at the local (degree centrality), meso (subgraph centrality), and global (eigenvector and page-rank centralities) levels. In compared to NC, SCD subjects had isolated decrease of subgraph centrality in primary (somatomotor and visual) networks. aMCI subjects had decreased centralities at all 3 scales in associative (frontoparietal control, dorsal attention, limbic and default) networks. AD subjects had increased centrality at the global scale in all 7 networks. There was a positive association between MoCA scores and DC in the frontoparietal control network in SCD, a negative relationship between MMSE scores and EC in the somatomotor network in AD. These findings suggest that the primary network is impaired as early as in SCD. Impairment in the associative network also starts at the...