Connectome analysis of functional and structural hemispheric brain networks in major depressive disorder

作者：Xueyan Jiang, Yuedi Shen, Jiashu Yao, Lei Zhang, Luoyi Xu, Rui Feng, Liqiang Cai, Jing Liu, Wei Chen, Jinhui Wang · 发表于：Translational Psychiatry · 年份：2019 · DOI：10.1038/s41398-019-0467-9 · 被引用次数：121 · 研究领域：Functional Brain Connectivity Studies、Advanced Neuroimaging Techniques and Applications、Mental Health Research Topics

Neuroimaging studies have shown topological disruptions of both functional and structural whole-brain networks in major depressive disorder (MDD). This study examined common and specific alterations between these two types of networks and whether the alterations were differentially involved in the two hemispheres. Multimodal MRI data were collected from 35 MDD patients and 35 healthy controls, whose functional and structural hemispheric networks were constructed, characterized, and compared. We found that functional brain networks were profoundly altered at multiple levels, while structural brain networks were largely intact in patients with MDD. Specifically, the functional alterations included decreases in intra-hemispheric (left and right) and inter-hemispheric (heterotopic) functional connectivity; decreases in local, global and normalized global efficiency for both hemispheric networks; increases in normalized local efficiency for the left hemispheric networks; and decreases in intra-hemispheric integration and inter-hemispheric communication in the dorsolateral superior frontal gyrus, anterior cingulate gyrus and hippocampus. Regarding hemispheric asymmetry, largely similar patterns were observed between the functional and structural networks: the right hemisphere was over-connected and more efficient than the left hemisphere globally; the occipital and partial regions exhibited leftward asymmetry, and the frontal and temporal sites showed rightward lateralization with ...