Metal-Free Aerobic Oxidative Selective C–C Bond Cleavage in Heteroaryl-Containing Primary and Secondary Alcohols

作者：Anjie Xia, Xueyu Qi, Xin Mao, Xiaoai Wu, Xin Yang, Rong Zhang, Zhiyu Xiang, Zhong Lian, Ying‐Chun Chen, Shengyong Yang · 发表于：Organic Letters · 年份：2019 · DOI：10.1021/acs.orglett.9b00563 · 被引用次数：30 · 研究领域：Catalytic C–H Functionalization Methods、Oxidative Organic Chemistry Reactions、Asymmetric Synthesis and Catalysis

A transition-metal-free aerobic oxidative selective C-C bond-cleavage reaction in primary and secondary heteroaryl alcohols is reported. This reaction was highly efficient and tolerated various heteroaryl alcohols, generating a carboxylic acid derivative and a neutral heteroaromatic compound. Experimental studies combined with density functional theory calculations revealed the mechanism underlying the selective C-C bond cleavage. This strategy also provides an alternative simple approach to carboxylation reaction.