Stereoselective Pd-Catalyzed Decarboxylative Allylation: Assembly of Highly Functionalized Allylic Amines Bearing a Quaternary Center

作者：Linlin Shi, Yingdong He, Yuanyuan Chang, Nan Zheng, Zhen Yang, Jianxian Gong · 发表于：Organic Letters · 年份：2019 · DOI：10.1021/acs.orglett.9b00673 · 被引用次数：19 · 研究领域：Asymmetric Synthesis and Catalysis、Synthetic Organic Chemistry Methods、Catalytic C–H Functionalization Methods

Here, we report a practical and reliable methodology to direct construction of tri- and tetrasubstituted olefins bearing an allylic amine, with the concomitant construction of the sterically congested quaternary stereocenter through stereoselective palladium-catalyzed cascade decarboxylation of vinyloxazolidinones.