Commensal Escherichia coli Aggravates Acute Necrotizing Pancreatitis through Targeting of Intestinal Epithelial Cells

作者：Junyuan Zheng, Lihong Lou, Junjie Fan, Chunlan Huang, Qixiang Mei, Jianghong Wu, Yuecheng Guo, Yingying Lu, Xingpeng Wang, Yue Zeng · 发表于：Applied and Environmental Microbiology · 年份：2019 · DOI：10.1128/aem.00059-19 · 被引用次数：73 · 研究领域：Pancreatitis Pathology and Treatment、Pancreatic and Hepatic Oncology Research、Gastrointestinal disorders and treatments

This study describes the harmful potential of commensal E. coli in ANP, which has not been demonstrated in previous studies. Our work provides new insights into gut bacterium-ANP cross talk, suggesting that nonpathogenic commensals could also exhibit adverse effects in the context of diseases.