Microfluidic Technology for Nucleic Acid Aptamer Evolution and Application

作者：Lewis A. Fraser, Yee‐Wai Cheung, Andrew B. Kinghorn, Wei Guo, Simon Chi‐Chin Shiu, Chandra Jinata, Mengping Liu, Soubhagya Kumar Bhuyan, Lang Nan, Ho Cheung Shum, Julian A. Tanner · 发表于：Advanced Biosystems · 年份：2019 · DOI：10.1002/adbi.201900012 · 被引用次数：32 · 研究领域：Advanced biosensing and bioanalysis techniques、Biosensors and Analytical Detection、Innovative Microfluidic and Catalytic Techniques Innovation

The intersection of microfluidics and aptamer technologies holds particular promise for rapid progress in a plethora of applications across biomedical science and other areas. Here, the influence of microfluidics on the field of aptamers, from traditional capillary electrophoresis approaches through innovative modern-day approaches using micromagnetic beads and emulsion droplets, is reviewed. Miniaturizing aptamer-based bioassays through microfluidics has the potential to transform diagnostics and embedded biosensing in the coming years.