Research progress on the PI3K/AKT signaling pathway in gynecological cancer (Review)

作者：Xiang Shi, Jingjing Wang, Lei Yu, Caofan Cong, Dailin Tan, Xianrong Zhou · 发表于：Molecular Medicine Reports · 年份：2019 · DOI：10.3892/mmr.2019.10121 · 被引用次数：235 · 研究领域：PI3K/AKT/mTOR signaling in cancer、Cancer Mechanisms and Therapy、Advanced Breast Cancer Therapies

The phosphatidylinositol 3‑kinase (PI3K)/protein kinase B (AKT) signaling pathway is involved in the regulation of multiple cellular physiological processes by activating downstream corresponding effector molecules, which serve an important role in the cell cycle, growth and proliferation. This is a common phenomenon; overactivation of the pathway is present in human malignancies and has been implicated in cancer progression, hence one of the important approaches to the treatment of tumors is rational drug design using molecular targets in the PI3K/AKT signaling pathway. In brief, the present review analyzed the effects of the PI3K/AKT signaling pathway on certain gynecological cancer types.