Palladium-Catalyzed Electrochemical C–H Bromination Using NH 4 Br as the Brominating Reagent

作者：Qi‐Liang Yang, Xiangyang Wang, Tong-Lin Wang, Yang Xiang, Dong Liu, Xiaofeng Tong, Xin‐Yan Wu, Tian‐Sheng Mei · 发表于：Organic Letters · 年份：2019 · DOI：10.1021/acs.orglett.9b00629 · 被引用次数：81 · 研究领域：Catalytic C–H Functionalization Methods、Oxidative Organic Chemistry Reactions、Radical Photochemical Reactions

The palladium-catalyzed electrochemical C–H bromination of benzamide derivatives under divided cells is developed, in which NH 4 Br serves as a brominating reagent and electrolyte. The protocol avoids the use of chemical oxidants and provides an alternative method for the synthesis of aryl bromides.