GPx4 in Bacterial Infection and Polymicrobial Sepsis: Involvement of Ferroptosis and Pyroptosis

作者：Hong Zhu, Arben Santo, Zhenquan Jia, Yichen Li · 年份：2019 · DOI：10.20455/ros.2019.835 · 被引用次数：79 · 研究领域：Inflammasome and immune disorders、Neutrophil, Myeloperoxidase and Oxidative Mechanisms、Ferroptosis and cancer prognosis

While it is well known that bacterial infection is the predominant cause of sepsis, the molecular pathophysiology of this clinical syndrome remains ill-defined. In this Research Highlights article, we discuss the recent research findings regarding a protective role for glutathione peroxidase-4 (GPx4) in bacterial infection and polymicrobial sepsis via modulating ferroptosis and pyroptosis, two novel modes of regulated cell death. It is suggested that GPx4, being a requisite gateway to both ferroptosis and pyroptosis, may serve as a critical molecular target for developing effective drugs for controlling infection and sepsis.