Mitochondrial stress delays tumorigenesis in a Li-Fraumeni syndrome mouse model

作者：Matthew P. Donnelly, Jie Li, Paul M. Hwang · 发表于：Cell Stress · 年份：2019 · DOI：10.15698/cst2019.04.182 · 被引用次数：2 · 研究领域：Cancer-related Molecular Pathways、Epigenetics and DNA Methylation、Cancer, Hypoxia, and Metabolism

Mitochondrial stress delays tumorigenesis in a Li-Fraumeni syndrome mouse model – As a prominent hub of metabolic activity, the mitochondrion can initiate retrograde signaling in response to bioenergetic stress that is important for various adaptive changes including cell cycle regulation [1][2]. There is abundant evidence that cancer cells display alterations in metabolism, such as increased mitochondrial fatty acid oxidation [3][4], while noncanonical functions of p53 including (...)