Low vitamin D is associated with diabetes peripheral neuropathy in older but not in young and middle‐aged patients

作者：Yang Niu, Ji Li, Rongxia Peng, Xuelin Zhao, Jiang Wu, Qingya Tang · 发表于：Diabetes/Metabolism Research and Reviews · 年份：2019 · DOI：10.1002/dmrr.3162 · 被引用次数：25 · 研究领域：Vitamin D Research Studies、Pain Mechanisms and Treatments、Bone health and osteoporosis research

BACKGROUND: The relationship between vitamin D and diabetes peripheral neuropathy (DPN) is not consistent among epidemiologic studies. Thus, we aimed to investigate this relationship in different age groups. METHODS: In this cross-sectional study, 1461 patients admitted to the Department of Endocrinology at Xinhua Hospital from June 2016 to September 2017 were divided into three age groups: a Youth group (24-44 years, n = 127), a Middle-age group (45-64 years, n = 779), and an Elderly group (≥65 years, n = 555). Basic information and laboratory results were collected from medical records. RESULTS: Among the patients, 32.72% had DPN, with 12.59% in the Youth group, 33.63% in the Middle-age group, and 36.04% in the Elderly group. For the total sample and the Elderly group, serum 25(OH)D concentrations in DPN patients were lower than in non-DPN patients (P < .05). The results of multivariate logistic regression indicated a low vitamin D concentration to be a risk factor for DPN in the Elderly group (P < .05), but such relationship was not found in the Youth or Middle-age groups. Moreover, according to ROC analysis, a serum 25(OH)D level < 34.87 nmol/L suggests the occurrence of DPN in elderly patients with type 2 diabetes (P < .001). CONCLUSIONS: This study is the first to report that a low vitamin D level is associated with DPN in diabetic patients over 65 years of age and might be used as a predictor of DPN in this population. The interaction between vitamin D and age in the d...