Transition Metal‐Free C5 Tosyloxylation of 8‐Aminoquinolines with Phenyliodine Bistrifluoroacetate and Substituted 1,2‐Disulfonyl Hydrazides

作者：Tingting Liang, Xin He, Dezhong Ji, Huanhuan Wu, Yizhu Xu, Yizhu Xu, Yuyan Li, Zhibin Wang, Yungen Xu, Yungen Xu, Qihua Zhu · 发表于：European Journal of Organic Chemistry · 年份：2019 · DOI：10.1002/ejoc.201900092 · 被引用次数：14 · 研究领域：Catalytic C–H Functionalization Methods、Sulfur-Based Synthesis Techniques、Synthesis and Catalytic Reactions

A novel and efficient method for direct tosyloxylation at C5 position of 8‐aminoquinolines has been accomplished by nonmetal‐catalyzed C–H functionalization at mild conditions. It is shown, for the first time, that the radical RSO 3 · could be generated by the reaction of phenyliodine bistrifluoroacetate with substituted 1,2‐disulfonyl hydrazides. This reaction reveals excellent reactivity, good functional group tolerance, and moderate to good yield.