Evidence for liver energy metabolism programming in offspring subjected to intrauterine undernutrition during midgestation

作者：Xiaoling Zhou, Hong Yang, Qiongxian Yan, Ao Ren, Zhiwei Kong, Shaoxun Tang, Xuefeng Han, Zhiliang Tan, Abdelfattah Z. M. Salem · 发表于：Nutrition & Metabolism · 年份：2019 · DOI：10.1186/s12986-019-0346-7 · 被引用次数：34 · 研究领域：Birth, Development, and Health、Gestational Diabetes Research and Management、Child Nutrition and Water Access

Maternal undernutrition programs fetal energy homeostasis and increases the risk of metabolic disorders later in life. This study aimed to identify the signs of hepatic metabolic programming in utero and during the juvenile phase after intrauterine undernutrition during midgestation. Fifty-three pregnant goats were assigned to the control (100% of the maintenance requirement) or restricted (60% of the maintenance requirement from day 45 to day 100 of midgestation and realimentation thereafter) group to compare hepatic energy metabolism in the fetuses (day 100 of gestation) and kids (postnatal day 90). Undernutrition increased the glucagon concentration and hepatic hexokinase activity, decreased the body weight, liver weight and hepatic expression of G6PC , G6PD , and PGC1α mRNAs, and tended to decrease the hepatic glycogen content and ACOX1 mRNA level in the dams. Maternal undernutrition decreased the growth hormone (GH) and triglyceride concentrations, tended to decrease the body weight and hepatic hexokinase activity, increased the hepatic PCK1 , PCK2 and PRKAA2 mRNAs levels and glucose-6-phosphatase activity, and tended to increase the hepatic PRKAB1 and CPT1α mRNAs levels in the male fetuses. In the restricted female fetuses, the hepatic hexokinase activity and G6PC mRNA level tended to be increased, but PKB1 mRNA expression was decreased and the ACACA , CPT1α , NR1H3 and STK11 mRNA levels tended to be decreased. Maternal undernutrition changed the hepatic metabolic profi...