Sexual dimorphisms in the transcriptomes of murine salivary glands

作者：Taro Mukaibo, Xin Gao, Ning‐Yan Yang, Maria S. Oei, Tetsuji Nakamoto, James E. Melvin · 发表于：FEBS Open Bio · 年份：2019 · DOI：10.1002/2211-5463.12625 · 被引用次数：29 · 研究领域：Salivary Gland Disorders and Functions、Thyroid Disorders and Treatments

Transcriptional profiling identified 933 sexually dimorphic genes out of the 14 371 protein-coding genes expressed in the three major murine salivary glands: parotid, sublingual, and submandibular. Most (89%) sex-specific genes were enriched in a single gland, while only 0.5% of the sexually dimorphic genes were enriched in all glands. The sublingual gland displayed a strong male sex bias (94% of sex-enriched genes), while a sex preference was not obvious in the parotid or submandibular glands. A subset of transcription factor genes was correlated with the expression of gland-specific, sex-enriched genes. Higher expression of Cftr chloride and Scnn1 sodium channels in the male submandibular correlated with greater NaCl reabsorption. In conclusion, adult salivary glands display sex- and gland-specific differences in gene expression that reflect their unique functional properties.