The trajectory of functional decline over the last 4 months of life in a palliative care population: A prospective, consecutive cohort study

作者：Deidre D. Morgan, Jennifer Tieman, Samuel F Allingham, Magnus Ekström, Alanna M Connolly, David C. Currow · 发表于：Palliative Medicine · 年份：2019 · DOI：10.1177/0269216319839024 · 被引用次数：49 · 研究领域：Palliative Care and End-of-Life Issues、Frailty in Older Adults、Cancer survivorship and care

BACKGROUND: Understanding current patterns of functional decline will inform patient care and has health service and resource implications. AIM: This prospective consecutive cohort study aims to map the shape of functional decline trajectories at the end of life by diagnosis. DESIGN: Changes in functional status were measured using the Australia-modified Karnofsky Performance Status Scale. Segmented regression was used to identify time points prior to death associated with significant changes in the slope of functional decline for each diagnostic cohort. Sensitivity analyses explored the impact of severe symptoms and late referrals, age and sex. SETTING/PARTICIPANTS: In all, 115 specialist palliative care services submit prospectively collected patient data to the national Palliative Care Outcomes Collaboration across Australia. Data on 55,954 patients who died in the care of these services between 1 January 2013 and 31 December 2015 were included. RESULTS: Two simplified functional decline trajectories were identified in the last 4 months of life. Trajectory 1 has an almost uniform slow decline until the last 14 days of life when function declines more rapidly. Trajectory 2 has a flatter more stable trajectory with greater functional impairment at 120 days before death, followed by a more rapid decline in the last 2 weeks of life. The most rapid rate of decline occurs in the last 2 weeks of life for all cohorts. CONCLUSIONS: Two simplified trajectories of functional decline ...