Towards Novel Photodynamic Anticancer Agents Generating Superoxide Anion Radicals: A Cyclometalated Ir III Complex Conjugated to a Far‐Red Emitting Coumarin

作者：Vojtěch Novohradský, Anna Rovira, Cormac Hally, Alex Galindo, Gloria Vigueras, Albert Gandioso, Marie Svitelova, Roger Bresolí‐Obach, Hana Kostrhunová, Lenka Marková, Jana Kašpárková, Santi Nonell, José Ruiz, Viktor Brabec, Vicente Marchán · 发表于：Angewandte Chemie International Edition · 年份：2019 · DOI：10.1002/anie.201901268 · 被引用次数：203 · 研究领域：Nanoplatforms for cancer theranostics、Luminescence and Fluorescent Materials、Photodynamic Therapy Research Studies

Abstract Although cyclometalated Ir III complexes have emerged as promising photosensitizers for photodynamic therapy, some key drawbacks still hamper clinical translation, such as operability in the phototherapeutic window and reactive oxygen species (ROS) production efficiency and selectivity. In this work, a cyclometalated Ir III complex conjugated to a far‐red‐emitting coumarin, Ir III –COUPY, is reported with highly favourable properties for cancer phototherapy. Ir III –COUPY was efficiently taken up by HeLa cells and showed no dark cytotoxicity and impressive photocytotoxicity indexes after irradiation with green and blue light, even under hypoxia. Importantly, a clear correlation between cell death and intracellular generation of superoxide anion radicals after visible light irradiation was demonstrated. This strategy opens the door to novel fluorescent photodynamic therapy agents with promising applications in theragnosis.