Association Between Tumor Compartment Volumes, the Incidence of Pretreatment Seizures, and Statin-Mediated Protective Effects in Glioblastoma

作者：Christian Henker, Thomas Kriesen, Moritz Scherer, Änne Glass, Andreas von Deimling, Martin Bendszus, Marc‐André Weber, Christel Herold‐Mende, Andreas Unterberg, Jürgen Piek · 发表于：Neurosurgery · 年份：2019 · DOI：10.1093/neuros/nyz079 · 被引用次数：23 · 研究领域：Cancer, Lipids, and Metabolism、Glioma Diagnosis and Treatment、Ferroptosis and cancer prognosis

BACKGROUND: Seizures are a common initial symptom of malignant brain tumors such as glioblastoma (GBM). However, why some of these tumors are epileptogenic and others never trigger seizures remains controversial. OBJECTIVE: To identify potential clinical and radiological features of epileptogenic tumors and the effect of initial seizures on survival. METHODS: The analyzed patient cohort was retrospectively compiled (bicentric), only isocitrate dehydrogenase wild-type GBMs were included. Volumetric assessment was performed on pretreatment magnetic resonance imaging with the aid of a semi-automated 3D measurement (tumor, necrosis, and edema volume). Two ratios were calculated, reflecting the proportion of peritumoral edema and necrosis (NTR) toward the tumor volume. For overall survival analyses, only patients after a surgical resection (residual tumor volume <2 cm3) followed by standard radiation and chemotherapy were included. RESULTS: Pretreatment seizures occurred in 33% of cases (n = 224), younger patients (≤60 yr) were predominantly affected (P = .022). All measured volumes were inversely correlated with the onset of seizures (P = .001). In multivariate analyses, the total tumor volume and the NTR were considerably smaller within epileptogenic GBMs (P = .050, P = .019, respectively). A positive statin intake was associated with significantly lesser seizure (P = .007, odds ratio 4.94). Neither the occurrence of seizures nor the intake of statins had an impact on OS (P = .3...