Randomised controlled trial of WISENSE, a real-time quality improving system for monitoring blind spots during esophagogastroduodenoscopy

作者：Lianlian Wu, Jun Zhang, Wei Zhou, Ping An, Lei Shen, Jun Liu, Xiaoda Jiang, Xu Huang, Ganggang Mu, Xinyue Wan, Xiaoguang Lv, Juan Gao, Ning Cui, Shan Hu, Yiyun Chen, Xiao Hu, Jiangjie Li, Di Chen, Dexin Gong, Xinqi He, Qianshan Ding, Xiaoyun Zhu, Suqin Li, Xiao Wei, Xia Li, Xuemei Wang, Jie Zhou, Mengjiao Zhang, Hong Yu · 发表于：Gut · 年份：2019 · DOI：10.1136/gutjnl-2018-317366 · 被引用次数：320 · 研究领域：Esophageal Cancer Research and Treatment、Colorectal Cancer Screening and Detection、Gastric Cancer Management and Outcomes

OBJECTIVE: Esophagogastroduodenoscopy (EGD) is the pivotal procedure in the diagnosis of upper gastrointestinal lesions. However, there are significant variations in EGD performance among endoscopists, impairing the discovery rate of gastric cancers and precursor lesions. The aim of this study was to construct a real-time quality improving system, WISENSE, to monitor blind spots, time the procedure and automatically generate photodocumentation during EGD and thus raise the quality of everyday endoscopy. DESIGN: WISENSE system was developed using the methods of deep convolutional neural networks and deep reinforcement learning. Patients referred because of health examination, symptoms, surveillance were recruited from Renmin hospital of Wuhan University. Enrolled patients were randomly assigned to groups that underwent EGD with or without the assistance of WISENSE. The primary end point was to ascertain if there was a difference in the rate of blind spots between WISENSE-assisted group and the control group. RESULTS: WISENSE monitored blind spots with an accuracy of 90.40% in real EGD videos. A total of 324 patients were recruited and randomised. 153 and 150 patients were analysed in the WISENSE and control group, respectively. Blind spot rate was lower in WISENSE group compared with the control (5.86% vs 22.46%, p<0.001), and the mean difference was -15.39% (95% CI -19.23 to -11.54). There was no significant adverse event. CONCLUSIONS: WISENSE significantly reduced blind spot...