A non-invasive diagnostic model of immunoglobulin A nephropathy and serological markers for evaluating disease severity

作者：Qiuxia Han, Yong Wang, Hanyu Zhu, Dong Zhang, Jing Gao, Zhangsuo Liu, Guangyan Cai, Xiangmei Chen · 发表于：Chinese Medical Journal · 年份：2019 · DOI：10.1097/cm9.0000000000000121 · 被引用次数：9 · 研究领域：Renal Diseases and Glomerulopathies、Nephrotoxicity and Medicinal Plants、Kidney Stones and Urolithiasis Treatments

BACKGROUND: Immunoglobulin A nephropathy (IgAN) is the most common pathological type of glomerular disease. Kidney biopsy, the gold standard for IgAN diagnosis, has not been routinely applied in hospitals worldwide due to its invasion nature. Thus, we aim to establish a non-invasive diagnostic model and determine markers to evaluate disease severity by analyzing the serological parameters and pathological stages of patients with IgAN. METHODS: A total of 272 biopsy-diagnosed IgAN inpatients and 518 non-IgA nephropathy inpatients from the Department of Nephrology of Chinese People's Liberation Army General Hospital were recruited for this study. Routine blood examination, blood coagulation testing, immunoglobulin-complement testing, and clinical biochemistry testing were conducted and pathological stages were analyzed according to Lee grading system. The serological parameters and pathological stages were analyzed. The receiver operating characteristic (ROC) analysis was performed to estimate the diagnostic value of the clinical factors. Logistic regression was used to establish the diagnostic model. RESULTS: There were 15 significantly different serological parameters between the IgAN and non-IgAN groups (all P < 0.05). The ROC analysis was performed to measure the diagnostic value for IgAN of these parameters and the results showed that the area under the ROC curve (AUC) of total protein (TP), total cholesterol (TC), fibrinogen (FIB), D-dimer (D2), immunoglobulin A (IgA), an...