Global Disease Burden Estimates of Respiratory Syncytial Virus–Associated Acute Respiratory Infection in Older Adults in 2015: A Systematic Review and Meta-Analysis

作者：Ting Shi, Angéline Denouel, Anna Katharina Tietjen, Iain H. Campbell, Emily Moran, Xue Li, Harry J. Campbell, Clarisse Demont, Bryan O. Nyawanda, Helen Y. Chu, Sonia Stoszek, Anand Krishnan, Peter Openshaw, Ann Regina Falsey, Harish Nair, RESCEU Investigators, Harish Nair, Harry J. Campbell, Ting Shi, Shanshan Zhang, You Li, Peter Openshaw, Jadwicha Wedzicha, Ann Regina Falsey, Mark JS Miller, Philippe Beutels, Louis J Bont, Andrew John Pollard, Eva Molero, Federico Martinón‐Torres, Terho Heikkinen, Adam Meijer, Thea Kølsen Fischer, Maarten van den Berge, Carlo Giaquinto, Rafael Mikolajczyk, Judy Hackett, Bing Cai, Charles A Knirsch, Amanda Leach, Sonia K Stoszek, Scott Gallichan, Alexia Kieffer, Clarisse Demont, Angéline Denouel, Arnaud Chéret, Sandra Gavart, Jeroen Aerssens, Robert Fuentes, Brian Roy Rosen, Harish Nair, Harry J. Campbell, Ting Shi, Shanshan Zhang, You Li, Peter Openshaw, Jadwicha Wedzicha, Ann Regina Falsey, Mark JS Miller, Philippe Beutels, Louis J Bont, Andrew John Pollard, Eva Molero, Federico Martinón‐Torres, Terho Heikkinen, Adam Meijer, Thea Kølsen Fischer, Maarten van den Berge, Carlo Giaquinto, Rafael Mikolajczyk, Judy Hackett, Bing Cai, Charles A Knirsch, Amanda Leach, Sonia K Stoszek, Scott Gallichan, Alexia Kieffer, Clarisse Demont, Angéline Denouel, Arnaud Chéret, Sandra Gavart, Jeroen Aerssens, Robert Fuentes, Brian Roy Rosen · 发表于：The Journal of Infectious Diseases · 年份：2019 · DOI：10.1093/infdis/jiz059 · 被引用次数：545 · 研究领域：Respiratory viral infections research、Pneumonia and Respiratory Infections、Tracheal and airway disorders

Respiratory syncytial virus-associated acute respiratory infection (RSV-ARI) constitutes a substantial disease burden in older adults aged ≥65 years. We aimed to identify all studies worldwide investigating the disease burden of RSV-ARI in this population. We estimated the community incidence, hospitalization rate, and in-hospital case-fatality ratio (hCFR) of RSV-ARI in older adults, stratified by industrialized and developing regions, using data from a systematic review of studies published between January 1996 and April 2018 and 8 unpublished population-based studies. We applied these rate estimates to population estimates for 2015 to calculate the global and regional burdens in older adults with RSV-ARI in the community and in hospitals for that year. We estimated the number of in-hospital deaths due to RSV-ARI by combining hCFR data with hospital admission estimates from hospital-based studies. In 2015, there were about 1.5 million episodes (95% confidence interval [CI], .3 million-6.9 million) of RSV-ARI in older adults in industrialized countries (data for developing countries were missing), and of these, approximately 14.5% (214 000 episodes; 95% CI, 100 000-459 000) were admitted to hospitals. The global number of hospital admissions for RSV-ARI in older adults was estimated at 336 000 hospitalizations (uncertainty range [UR], 186 000-614 000). We further estimated about 14 000 in-hospital deaths (UR, 5000-50 000) related to RSV-ARI globally. The hospital admission r...