Sustained B cell depletion by CD19-targeted CAR T cells is a highly effective treatment for murine lupus

作者：Rita G. Kansal, Noah Richardson, Indira Neeli, Saleem Khawaja, Damian Chamberlain, Marium Ghani, Qurat-ul-ain Ghani, Louisa Balázs, Šárka Beranová-Giorgianni, Francesco Giorgianni, James N. Kochenderfer, Tony N. Marion, Lorraine M. Albritton, Marko Radic · 发表于：Science Translational Medicine · 年份：2019 · DOI：10.1126/scitranslmed.aav1648 · 被引用次数：379 · 研究领域：CAR-T cell therapy research、Immune Cell Function and Interaction、T-cell and B-cell Immunology

B cells and reduced disease in naive autoimmune mice, indicating that disease control was cell-mediated. Sustained B cell depletion with CD19-targeted CAR T cell immunotherapy is a stable and effective strategy to treat murine lupus, and its effectiveness should be explored in clinical trials for lupus.