Temperature- and rigidity-mediated rapid transport of lipid nanovesicles in hydrogels

作者：Miaorong Yu, Wenyi Song, Falin Tian, Zhuo Dai, Quanlei Zhu, Ejaj Ahmad, Shiyan Guo, Chunliu Zhu, Haijun Zhong, Yongchun Yuan, Tao Zhang, Xin Yi, Xinghua Shi, Yong Gan, Huajian Gao · 发表于：Proceedings of the National Academy of Sciences · 年份：2019 · DOI：10.1073/pnas.1818924116 · 被引用次数：148 · 研究领域：Lipid Membrane Structure and Behavior、RNA Interference and Gene Delivery、Advancements in Transdermal Drug Delivery

Significance Lipid vesicles such as liposomes are widely present in biological systems and drug delivery applications. Numerous studies have focused on their roles in intercellular communication, signaling, and trafficking. Little is known, however, about the correlation between temperature and transport rate of these vesicles in biological media. Here, we report a temperature- and rigidity-mediated rapid transport mechanism by which liposomes attain optimal diffusivity near a phase transition temperature. Remarkably, liposomes with phase transition temperature around the body temperature are observed to overcome multiple biological barriers and show substantial improvement in drug delivery efficacy.