Absence of GdX/UBL4A Protects against Inflammatory Diseases by Regulating NF-кB Signaling in Macrophages and Dendritic Cells

作者：Chunxiao Liu, Yifan Zhou, Mengdi Li, Ying Wang, Yang Liu, Shigao Yang, Yarui Feng, Yinyin Wang, Yangmeng Wang, Fangli Ren, Jun Li, Zhongjun Dong, Y. Eugene Chin, Xin‐Yuan Fu, Wu Li, Zhijie Chang · 发表于：Theranostics · 年份：2019 · DOI：10.7150/thno.32451 · 被引用次数：29 · 研究领域：Immune Response and Inflammation、Immunotherapy and Immune Responses、NF-κB Signaling Pathways

Our study provides a mechanism by which NF-κB signaling is positively regulated by an adaptor protein GdX in DC or Mφ to maintain the innate immune response. Targeting GdX could be a strategy to reduce over-activated immune response in inflammatory diseases.