POCl 3 promoted metal-free synthesis of tertiary amides by coupling of carboxylic acids and N,N -disubstituted formamides

作者：Xiaojing Bi, Junchen Li, Enxue Shi, Li Yu, Ying Liu, Hongmei Wang, Junhua Xiao · 发表于：Phosphorus, sulfur, and silicon and the related elements · 年份：2019 · DOI：10.1080/10426507.2018.1539991 · 被引用次数：6 · 研究领域：Chemical Synthesis and Analysis、Advanced Synthetic Organic Chemistry、Asymmetric Hydrogenation and Catalysis

Xiaojing Bia, Junchen Lia, Enxue Shia, Yu Lia, Ying Liua, Hongmei Wanga & Junhua Xiaoa*a State Key Laboratory of NBC Protection for Civilian, Beijing, PR ChinaCONTACT Junhua Xiao xiao.junhua@pku.edu.cnSupplemental data for this article can be accessed on the publisher’s website at https://doi.org/10.1080/10426507.2018.1539991.AbstractHerein we report a robust and synthetically useful catalyst-free amination methodology by the coupling of carboxylic acids and N-substituted formamides using POCl3 as a promoter. Versatile amides with a wide array of substituent groups were prepared within only 1 h in good to excellent yields. And even multi-substituted aromatic carboxylic acids could give the desired products with satisfactory results.Graphical Abstract