Molecular Mechanisms of Plant Regeneration

作者：Momoko Ikeuchi, David S. Favero, Yuki Sakamoto, Akira Iwase, Duncan Coleman, Bart Rymen, Keiko Sugimoto · 发表于：Annual Review of Plant Biology · 年份：2019 · DOI：10.1146/annurev-arplant-050718-100434 · 被引用次数：518 · 研究领域：Plant Molecular Biology Research、Plant tissue culture and regeneration、Plant Reproductive Biology

Plants reprogram somatic cells following injury and regenerate new tissues and organs. Upon perception of inductive cues, somatic cells often dedifferentiate, proliferate, and acquire new fates to repair damaged tissues or develop new organs from wound sites. Wound stress activates transcriptional cascades to promote cell fate reprogramming and initiate new developmental programs. Wounding also modulates endogenous hormonal responses by triggering their biosynthesis and/or directional transport. Auxin and cytokinin play pivotal roles in determining cell fates in regenerating tissues and organs. Exogenous application of these plant hormones enhances regenerative responses in vitro by facilitating the activation of specific developmental programs. Many reprogramming regulators are epigenetically silenced during normal development but are activated by wound stress and/or hormonal cues.