Isocoumarindole A, a Chlorinated Isocoumarin and Indole Alkaloid Hybrid Metabolite from an Endolichenic Fungus Aspergillus sp.

作者：Minghua Chen, Renzhong Wang, Wuli Zhao, Liyan Yu, Cong-Hui Zhang, Shanshan Chang, Yan Li, Tao Zhang, Jianguo Xing, Maoluo Gan, Feng Feng, Shuyi Si · 发表于：Organic Letters · 年份：2019 · DOI：10.1021/acs.orglett.9b00385 · 被引用次数：67 · 研究领域：Microbial Natural Products and Biosynthesis、Marine Sponges and Natural Products、Chemical synthesis and alkaloids

Isocoumarindole A (1), a novel polyketide synthetase-nonribosomal peptide synthetase (PKS-NRPS) hybrid metabolite, was isolated from the endolichenic fungus Aspergillus sp. CPCC 400810. The structure of isocoumarindole A (1) was featured by an unprecedented skeleton containing chlorinated isocoumarin and indole diketopiperazine alkaloid moieties linked by a carbon-carbon bond, which was determined by a combination of spectroscopic analyses, Marfey's method, and calculations of NMR chemical shifts, ECD spectra, and optical rotation values. Isocoumarindole A showed significant cytotoxicity and mild antifungal activities.