Microglial activation in early Alzheimer trajectory is associated with higher gray matter volume

作者：Grazia Daniela Femminella, Melanie Dani, Melanie Wood, Zhen Fan, Valeria Calsolaro, Rebecca Atkinson, Trudi Edginton, Rainer Hinz, David J. Brooks, Paul Edison · 发表于：Neurology · 年份：2019 · DOI：10.1212/wnl.0000000000007133 · 被引用次数：107 · 研究领域：Neuroinflammation and Neurodegeneration Mechanisms、Alzheimer's disease research and treatments、Neurological Disease Mechanisms and Treatments

OBJECTIVE: To investigate the influence of microglial activation in the early stages of Alzheimer's disease trajectory, we assessed the relationship between microglial activation and gray matter volume and hippocampal volume in patients with mild cognitive impairment (MCI). METHODS: F]flutemetamol PET. RESULTS: . CONCLUSIONS: C]PBR28 PET was associated with higher gray matter volume and higher hippocampal volume in patients with MCI. This might suggest that microglial activation may not always be associated with neuronal damage, and indeed it may have a beneficial effect in the early stages of the Alzheimer trajectory. While further longitudinal studies are necessary, these findings have significant implications on therapeutic strategies targeting microglial activation.