Bio-inspired nitric-oxide-driven nanomotor

作者：Mimi Wan, Huan Chen, Qi Wang, Qian Niu, Ping Xu, Yueqi Yu, Tianyu Zhu, Chun Mao, Jian Shen · 发表于：Nature Communications · 年份：2019 · DOI：10.1038/s41467-019-08670-8 · 被引用次数：298 · 研究领域：Micro and Nano Robotics、Molecular Communication and Nanonetworks、Nanoplatforms for cancer theranostics

, Pt). Here, inspired by endogenous biochemical reactions in the human body involving conversion of amino acid L-arginine to nitric oxide (NO) by NO synthase (NOS) or reactive oxygen species (ROS), we report on a nanomotor made of hyperbranched polyamide/L-arginine (HLA). The nanomotor utilizes L-arginine as fuel for the production of NO both as driving force and to provide beneficial effects, including promoting endothelialisation and anticancer effects, along with other beneficial by-products. In addition, the HLA nanomotors are fluorescent and can be used to monitor the movement of nanomotors in vivo in the future. This work presents a zero-waste, self-destroyed and self-imaging nanomotor with potential biological application for the treatment of various diseases in different tissues including blood vessels and tumours.