Critical appraisal of international guidelines for the screening and treatment of asymptomatic peripheral artery disease: a systematic review

作者：Qinchang Chen, Lingling Li, Qingui Chen, Xixia Lin, Yonghui Li, Kai Huang, Chen Yao · 发表于：BMC Cardiovascular Disorders · 年份：2019 · DOI：10.1186/s12872-018-0960-8 · 被引用次数：19 · 研究领域：Peripheral Artery Disease Management、Clinical practice guidelines implementation、Antiplatelet Therapy and Cardiovascular Diseases

BACKGROUND: Peripheral artery disease (PAD) is often asymptomatic but increases the risk of developing cardiovascular events. Due to the uncertainties regarding the quality of related guidelines and a lack of clear-cut evidence, we performed a systematic review and critical appraisal of these guidelines to evaluate their consistency of the recommendations in asymptomatic PAD population. METHODS: Guidelines in English between January 1st, 2000 to December 31th, 2017 were screened in databases including Medline via PubMed, EMBASE, the G-I-N International Guideline Library, the National Guidelines Clearinghouse, the Canadian Medication Association Infobase and the National Library for Health. Those guidelines containing recommendations on screening and treatment for asymptomatic PAD were included, and three reviewers evaluated the quality of the guidelines using Appraisal of Guidelines Research and Evaluation (AGREE) II instrument. Related recommendations were then fully extracted and compared by two reviewers. RESULTS: Fourteen guidelines were included finally and the AGREE scores ranged from 39 to 73%. Most of included guidelines scored low in Rigor of development and Editorial independence, and only two guidelines (ACCF/AHA, AHA/ACC) reached the standard on Conflict of Interest from Institute of Medicine (IOM). Eight guidelines recommended screening at different strength while the others found insufficient evidence or were against screening. Conflicting recommendations on tre...