Norascyronones A and B, 2,3,4-nor-Polycyclic Polyprenylated Acylphloroglucinols from Hypericum ascyron

作者：Yali Hu, Kun Hu, Lingmei Kong, Fan Xia, Xing‐Wei Yang, Gang Xu · 发表于：Organic Letters · 年份：2019 · DOI：10.1021/acs.orglett.8b04022 · 被引用次数：40 · 研究领域：Natural Compound Pharmacology Studies、Synthesis of Organic Compounds

Phytochemical study of Hypericum ascyron led to the characterization of norascyronones A–C ( 1 – 3 ), metabolites derived from bicyclic polyprenylated acylphloroglucinols by losing eight carbons (C-2/3/4 of core and the isoprenyl at C-3). Compounds 1 / 2 with an unprecedented 6/6/5/6 ring system should be generated via [4 + 2] intramolecular cyclization of 3 . Their structures were determined by spectroscopic and X-ray diffraction data. Compounds 1 and 2 showed cytotoxicities against the SK-BR-3 cell line (IC 50 4.3 and 7.8 μM).