Phenotypic Plasticity of Invasive Edge Glioma Stem-like Cells in Response to Ionizing Radiation

作者：Mutsuko Minata, Alessandra Audia, Junfeng Shi, Songjian Lu, Joshua D. Bernstock, Marat S. Pavlyukov, Arvid Das, Sung-Hak Kim, Yong Jae Shin, Yeri Lee, Harim Koo, Kirti Snigdha, Indrayani Waghmare, Xing Guo, Ahmed Mohyeldin, Daniel Gallego‐Perez, Jia Wang, Dongquan Chen, Peng Cheng, Farah Mukheef, Minerva Contreras, Joel F. Reyes, Brian D. Vaillant, Erik P. Sulman, Shi‐Yuan Cheng, James M. Markert, Bakhos A. Tannous, Xinghua Lu, Madhuri Kango‐Singh, L. James Lee, Do‐Hyun Nam, Ichiro Nakano, Krishna Bhat · 发表于：Cell Reports · 年份：2019 · DOI：10.1016/j.celrep.2019.01.076 · 被引用次数：225 · 研究领域：Hippo pathway signaling and YAP/TAZ、Cancer-related molecular mechanisms research、Autophagy in Disease and Therapy

cells are highly enriched with clonogenic, tumor-initiating, and radiation-resistant properties, and silencing CD109 significantly inhibits these phenotypes. We also report a conserved regulation of YAP/TAZ pathways by CD109 that could be a therapeutic target in GBM.